🟡Kisspeptin-10 | 5mg 🏆 Amber Edition

Kisspeptin-10 is a potent peptide belonging to the kisspeptin family, playing a crucial role in regulating the reproductive system. This peptide, derived from the KISS1 gene, acts by binding to the GPR54 receptor, also known as the kisspeptin receptor, which is integral in the regulation of the hypothalamic-pituitary-gonadal (HPG) axis. This axis is essential for reproductive hormone release and function.

Upon binding to GPR54, kisspeptin-10 activates intracellular signaling pathways, particularly the phospholipase C (PLC) pathway. This activation leads to an increase in intracellular calcium levels, which subsequently stimulates the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. The release of GnRH is a critical step in the regulation of the reproductive hormone cascade, leading to the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. These hormones are vital for gonadal function, including the production of sex steroids and gametogenesis.

Clinical and experimental studies have highlighted the significance of kisspeptin-10 in reproductive health. It has been shown to play a key role in the onset of puberty, the regulation of fertility, and the maintenance of normal reproductive function. In individuals with reproductive disorders, such as hypothalamic amenorrhea or idiopathic hypogonadotropic hypogonadism, kisspeptin-10 has been investigated as a potential therapeutic agent to stimulate the HPG axis and restore normal reproductive hormone levels.